Inhibition of Human Sulfotransferases by Phthalate Monoesters

Inhibition of Human Sulfotransferases by Phthalate Monoesters

ObjectiveThis study aimed to investigate the inhibition of human important phase II metabolic enzyme sulfotransferases (SULTs) by phthalate monoesters, which are important metabolites of phthalate esters (PAEs).MethodRecombinant SULT-catalyzed metabolism of p-nitrophenol (PNP) was employed as the pr...

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Bibliographic Details
Main Authors: Hui Huang, Bei-Di Lan, Yu-Jing Zhang, Xiao-Juan Fan, Min-Cui Hu, Guo-Qiang Qin, Fei-Ge Wang, Yue Wu, Tao Zheng, Jun-Hui Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Endocrinology
Subjects:
phthalate esters (PAEs)
sulfotransferases (SULTs)
enzyme inhibition
in silico docking
in vitro–in vivo extrapolation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.868105/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.868105/full

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