Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing

Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing

Culture pH is a critical process parameter during CHO cell bioreactor operations that is key for proper cell growth, protein production, and maintaining the critical quality attributes of a monoclonal antibody drug substance. The traditional means of measuring pH in bioreactors is with an electroche...

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Bibliographic Details
Main Authors: Erica J. Fratz-Berilla, Casey Kohnhorst, Nicholas Trunfio, Xin Bush, Aron Gyorgypal, Cyrus Agarabi
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Heliyon
Subjects:
Chinese hamster ovary cells
CHO
Process control
pH control
pH sensor
Monoclonal antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024015433

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http://www.sciencedirect.com/science/article/pii/S2405844024015433

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