Mimicking of Blood Flow Results in a Distinct Functional Phenotype in Human Non-Adherent Classical Monocytes

Mimicking of Blood Flow Results in a Distinct Functional Phenotype in Human Non-Adherent Classical Monocytes

Ex vivo culture conditions during the manufacturing process impact the therapeutic effect of cell-based products. Mimicking blood flow during ex vivo culture of monocytes has beneficial effects by preserving their migratory ability. However, the effects of shear flow on the inflammatory response hav...

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Bibliographic Details
Main Authors: Elisa Wirthgen, Melanie Hornschuh, Ida Maria Wrobel, Christian Manteuffel, Jan Däbritz
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biology
Subjects:
classical monocytes
shear flow
GM-CSF
phenotype
cytokine release
cellular therapy
Online Access:https://www.mdpi.com/2079-7737/10/8/748

Internet

https://www.mdpi.com/2079-7737/10/8/748

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