Pan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD)

Pan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD)

Abstract Homologous repair deficiency (HRD) is present in many cancer types at variable prevalence and can indicate response to platinum-based chemotherapy and PARP inhibition. We developed a tumor classification system based on the loss of function of genes in the homologous recombination repair (H...

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Bibliographic Details
Main Authors: E. Rempel, K. Kluck, S. Beck, I. Ourailidis, D. Kazdal, O. Neumann, A. L. Volckmar, M. Kirchner, H. Goldschmid, N. Pfarr, W. Weichert, D. Hübschmann, S. Fröhling, C. Sutter, C. P. Schaaf, P. Schirmacher, V. Endris, A. Stenzinger, J. Budczies
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-022-00276-6

Internet

https://doi.org/10.1038/s41698-022-00276-6

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