P2Y12 Receptor Antagonist Clopidogrel Attenuates Lung Inflammation Triggered by Silica Particles

P2Y12 Receptor Antagonist Clopidogrel Attenuates Lung Inflammation Triggered by Silica Particles

Silicosis is an occupational lung disease caused by inhalation of silica particles. It is characterized by intense lung inflammation, with progressive and irreversible fibrosis, leading to impaired lung function. Purinergic signaling modulates silica-induced lung inflammation and fibrosis through P2...

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Bibliographic Details
Main Authors: Patricia Teixeira Santana, Tatiana Luna-Gomes, Marcos Vinicius Rangel-Ferreira, Augusto Shuiti Tamura, Carolyne Lalucha Alves Lima Da Graça, Mariana Nascimento Machado, Walter Araujo Zin, Christina Maeda Takiya, Debora Souza Faffe, Robson Coutinho-Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
silica particles
silicosis
purinergic receptors
P2Y12 receptor
ADP
clopidogrel
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00301/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00301/full

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