Experimental and Meta-Analytic Validation of RNA Sequencing Signatures for Predicting Status of Microsatellite Instability

Experimental and Meta-Analytic Validation of RNA Sequencing Signatures for Predicting Status of Microsatellite Instability

Microsatellite instability (MSI) is an important diagnostic and prognostic cancer biomarker. In colorectal, cervical, ovarian, and gastric cancers, it can guide the prescription of chemotherapy and immunotherapy. In laboratory diagnostics of susceptible tumors, MSI is routinely detected by the size...

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Bibliographic Details
Main Authors: Maksim Sorokin, Elizaveta Rabushko, Victor Efimov, Elena Poddubskaya, Marina Sekacheva, Alexander Simonov, Daniil Nikitin, Aleksey Drobyshev, Maria Suntsova, Anton Buzdin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
microsatellite instability
RNA sequencing
NGS
RNAseq
gene signatures
experimental validation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.737821/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.737821/full

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