Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression

Abstract Our recent studies have indicated that specificity protein-1 (Sp1) accumulates substantially in the early stage of lung cancer but is partially decreased in the late stages, which is an important factor in the progression of the cancer. In this study, we found that Nm23-H1 and hnRNPA2/B1 co...

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Bibliographic Details
Main Authors: Chia-Yang Hung, Yi-Chang Wang, Jian-Ying Chuang, Ming-Jer Young, Hungjiun Liaw, Wen-Chang Chang, Jan-Jong Hung
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09558-7