Lethal Zika Virus Disease Models in Young and Older Interferon α/β Receptor Knock Out Mice

Lethal Zika Virus Disease Models in Young and Older Interferon α/β Receptor Knock Out Mice

The common small animal disease models for Zika virus (ZIKV) are mice lacking the interferon responses, but infection of interferon receptor α/β knock out (IFNAR−/−) mice is not uniformly lethal particularly in older animals. Here we sought to advance this model in regard to lethality for future cou...

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Bibliographic Details
Main Authors: Andrea Marzi, Jackson Emanuel, Julie Callison, Kristin L. McNally, Nicolette Arndt, Spencer Chadinha, Cynthia Martellaro, Rebecca Rosenke, Dana P. Scott, David Safronetz, Stephen S. Whitehead, Sonja M. Best, Heinz Feldmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Zika virus
strains
pathogenesis
animal model
IFNAR−/− mice
uniform lethality
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00117/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2018.00117/full

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