Finerenone, a Non-Steroidal Mineralocorticoid Receptor Antagonist, Reduces Vascular Injury and Increases Regulatory T-Cells: Studies in Rodents with Diabetic and Neovascular Retinopathy

Finerenone, a Non-Steroidal Mineralocorticoid Receptor Antagonist, Reduces Vascular Injury and Increases Regulatory T-Cells: Studies in Rodents with Diabetic and Neovascular Retinopathy

Vision loss in diabetic retinopathy features damage to the blood–retinal barrier and neovascularization, with hypertension and the renin–angiotensin system (RAS) having causal roles. We evaluated if finerenone, a non-steroidal mineralocorticoid receptor (MR) antagonist, reduced vascular pathology an...

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Bibliographic Details
Main Authors: Jack R. Jerome, Devy Deliyanti, Varaporn Suphapimol, Peter Kolkhof, Jennifer L. Wilkinson-Berka
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
finerenone
mineralocorticoid receptor
diabetic retinopathy
angiogenesis
Tregs
Online Access:https://www.mdpi.com/1422-0067/24/3/2334

Internet

https://www.mdpi.com/1422-0067/24/3/2334

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