A Comprehensive Overview of Globally Approved JAK Inhibitors

A Comprehensive Overview of Globally Approved JAK Inhibitors

Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling through the JAK-STAT pathway, which regulates the transcription of several genes involved in inflammatory, immune, and canc...

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Bibliographic Details
Main Authors: Ahmed M. Shawky, Faisal A. Almalki, Ashraf N. Abdalla, Ahmed H. Abdelazeem, Ahmed M. Gouda
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
JAK
synthesis
kinase inhibitory activity
pharmacological uses
binding mode/interactions
Online Access:https://www.mdpi.com/1999-4923/14/5/1001

Internet

https://www.mdpi.com/1999-4923/14/5/1001

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