CEBPA Overexpression Enhances β-Cell Proliferation and Survival

CEBPA Overexpression Enhances β-Cell Proliferation and Survival

A commonality between type 1 and type 2 diabetes is the decline in functional β-cell mass. The transcription factor Nkx6.1 regulates β-cell development and is integral for proper β-cell function. We have previously demonstrated that Nkx6.1 depends on c-Fos mediated upregulation and the nuclear hormo...

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Bibliographic Details
Main Authors: Peter N. Ellsworth, Jacob A. Herring, Aaron H. Leifer, Jason D. Ray, Weston S. Elison, Peter Daniel Poulson, Jacqueline E. Crabtree, Pam M. Van Ry, Jeffery S. Tessem
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biology
Subjects:
Nkx6.1
CEBPA
Nr4a3
ER Stress
Ire1a
beta cell
Online Access:https://www.mdpi.com/2079-7737/13/2/110

Internet

https://www.mdpi.com/2079-7737/13/2/110

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