Differential effect of histone H3.3 depletion on retroviral repression in embryonic stem cells

Differential effect of histone H3.3 depletion on retroviral repression in embryonic stem cells

Abstract Background Integration of retroviruses into the host genome can impair the genomic and epigenomic integrity of the cell. As a defense mechanism, epigenetic modifications on the proviral DNA repress retroviral sequences in mouse embryonic stem cells (ESC). Here, we focus on the histone 3 var...

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Bibliographic Details
Main Authors: Ayellet Tal, Jose David Aguilera, Igor Bren, Carmit Strauss, Sharon Schlesinger
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Clinical Epigenetics
Subjects:
H3.3
Turnover
Retrovirus
Embryonic stem cells
Epigenetic silencing
Trim28
Online Access:https://doi.org/10.1186/s13148-023-01499-5

Internet

https://doi.org/10.1186/s13148-023-01499-5

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