Role of gut-derived bacterial lipopolysaccharide and peripheral TLR4 in immobilization stress-induced itch aggravation in a mouse model of atopic dermatitis

Role of gut-derived bacterial lipopolysaccharide and peripheral TLR4 in immobilization stress-induced itch aggravation in a mouse model of atopic dermatitis

Abstract Psychological stress and intestinal leakage are key factors in atopic dermatitis (AD) recurrence and exacerbation. Here, we demonstrate the mechanism underlying bacterial translocation across intestinal epithelial barrier damaged due to stress and further aggravation of trimellitic anhydrid...

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Bibliographic Details
Main Authors: Da-Eun Cho, Joon-Pyo Hong, Yoongeun Kim, Ju Yeon Sim, Heenam Stanley Kim, Song-rae Kim, Bombi Lee, Hyo-Sung Cho, Ik-Hyun Cho, Sooan Shin, Mijung Yeom, Soon-Kyeong Kwon, In-Seon Lee, Hijoon Park, Kyuseok Kim, Dae-Hyun Hahm
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Atopic dermatitis
Stress
TLR4
Lipopolysaccharide
Itch
Gut microbiota
Online Access:https://doi.org/10.1038/s41598-024-56936-z

Internet

https://doi.org/10.1038/s41598-024-56936-z

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