PAK6: a potential anti-cancer target
p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor development. PAK6, initially cloned as an interac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2020-03-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100700&tlng=en |
| _version_ | 1818367843905830912 |
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| author | Chan-Chan Gong Tong-Tong Li Dong-Sheng Pei |
| author_facet | Chan-Chan Gong Tong-Tong Li Dong-Sheng Pei |
| author_sort | Chan-Chan Gong |
| collection | DOAJ |
| description | p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor development. PAK6, initially cloned as an interacting partner of the androgen receptor (AR), is associated with an array of cellular processes implicated in tumor progression. However, the full biological implications of PAK6 activity during cancer remain poorly understood. In this review, we assess our current understanding of the physiological roles of classical PAK6 functionality in mammals, in addition to its emerging role in tumorigenesis. |
| first_indexed | 2024-12-13T22:58:30Z |
| format | Article |
| id | doaj.art-acd0955e72114831b2637c17e8b4551c |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-13T22:58:30Z |
| publishDate | 2020-03-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-acd0955e72114831b2637c17e8b4551c2022-12-21T23:28:27ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902020-03-015610.1590/s2175-97902019000318315PAK6: a potential anti-cancer targetChan-Chan GongTong-Tong LiDong-Sheng Peihttps://orcid.org/0000-0002-8053-3741p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor development. PAK6, initially cloned as an interacting partner of the androgen receptor (AR), is associated with an array of cellular processes implicated in tumor progression. However, the full biological implications of PAK6 activity during cancer remain poorly understood. In this review, we assess our current understanding of the physiological roles of classical PAK6 functionality in mammals, in addition to its emerging role in tumorigenesis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100700&tlng=enPAK6androgen Receptor (AR)cancer therapymiRNAs |
| spellingShingle | Chan-Chan Gong Tong-Tong Li Dong-Sheng Pei PAK6: a potential anti-cancer target Brazilian Journal of Pharmaceutical Sciences PAK6 androgen Receptor (AR) cancer therapy miRNAs |
| title | PAK6: a potential anti-cancer target |
| title_full | PAK6: a potential anti-cancer target |
| title_fullStr | PAK6: a potential anti-cancer target |
| title_full_unstemmed | PAK6: a potential anti-cancer target |
| title_short | PAK6: a potential anti-cancer target |
| title_sort | pak6 a potential anti cancer target |
| topic | PAK6 androgen Receptor (AR) cancer therapy miRNAs |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100700&tlng=en |
| work_keys_str_mv | AT chanchangong pak6apotentialanticancertarget AT tongtongli pak6apotentialanticancertarget AT dongshengpei pak6apotentialanticancertarget |