Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammation
Both basic pathomechanisms underlying Alzheimer’s disease and some premises for stipulating a possible preventive role of some sirtuins, especially SIRT1 and SIRT3, protective against Alzheimer’s disease-related pathology, are discussed in this article. Sirtuins can inhibit some processes that under...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.962769/full |
| _version_ | 1811215585805074432 |
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| author | Mateusz Watroba Dariusz Szukiewicz |
| author_facet | Mateusz Watroba Dariusz Szukiewicz |
| author_sort | Mateusz Watroba |
| collection | DOAJ |
| description | Both basic pathomechanisms underlying Alzheimer’s disease and some premises for stipulating a possible preventive role of some sirtuins, especially SIRT1 and SIRT3, protective against Alzheimer’s disease-related pathology, are discussed in this article. Sirtuins can inhibit some processes that underlie Alzheimer’s disease-related molecular pathology (e.g., neuroinflammation, neuroinflammation-related oxidative stress, Aβ aggregate deposition, and neurofibrillary tangle formation), thus preventing many of those pathologic alterations at relatively early stages of their development. Subsequently, the authors discuss in details which mechanisms of sirtuin action may prevent the development of Alzheimer’s disease, thus promoting brain homeostasis in the course of aging. In addition, a rationale for boosting sirtuin activity, both with allosteric activators and with NAD+ precursors, has been presented. |
| first_indexed | 2024-04-12T06:25:05Z |
| format | Article |
| id | doaj.art-acd209ef0dab4728b54c185d806a0789 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T06:25:05Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-acd209ef0dab4728b54c185d806a07892022-12-22T03:44:12ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-08-011310.3389/fphys.2022.962769962769Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammationMateusz WatrobaDariusz SzukiewiczBoth basic pathomechanisms underlying Alzheimer’s disease and some premises for stipulating a possible preventive role of some sirtuins, especially SIRT1 and SIRT3, protective against Alzheimer’s disease-related pathology, are discussed in this article. Sirtuins can inhibit some processes that underlie Alzheimer’s disease-related molecular pathology (e.g., neuroinflammation, neuroinflammation-related oxidative stress, Aβ aggregate deposition, and neurofibrillary tangle formation), thus preventing many of those pathologic alterations at relatively early stages of their development. Subsequently, the authors discuss in details which mechanisms of sirtuin action may prevent the development of Alzheimer’s disease, thus promoting brain homeostasis in the course of aging. In addition, a rationale for boosting sirtuin activity, both with allosteric activators and with NAD+ precursors, has been presented.https://www.frontiersin.org/articles/10.3389/fphys.2022.962769/fullsirtuins (SIRTs)brain homeostasisneuroinf lammationalzheimer’s diseaseaging |
| spellingShingle | Mateusz Watroba Dariusz Szukiewicz Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammation Frontiers in Physiology sirtuins (SIRTs) brain homeostasis neuroinf lammation alzheimer’s disease aging |
| title | Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammation |
| title_full | Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammation |
| title_fullStr | Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammation |
| title_full_unstemmed | Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammation |
| title_short | Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammation |
| title_sort | sirtuins promote brain homeostasis preventing alzheimer s disease through targeting neuroinflammation |
| topic | sirtuins (SIRTs) brain homeostasis neuroinf lammation alzheimer’s disease aging |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.962769/full |
| work_keys_str_mv | AT mateuszwatroba sirtuinspromotebrainhomeostasispreventingalzheimersdiseasethroughtargetingneuroinflammation AT dariuszszukiewicz sirtuinspromotebrainhomeostasispreventingalzheimersdiseasethroughtargetingneuroinflammation |