Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins

Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins

Tumour hypoxia negatively impacts therapy outcomes and continues to be a major unsolved clinical problem. Nitroimidazoles are hypoxia selective compounds that become entrapped in hypoxic cells by forming drug-protein adducts. They are widely used as hypoxia diagnostics and have also shown promise as...

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Bibliographic Details
Main Authors: Faisal Bin Rashed, Alexandru Cezar Stoica, Dawn MacDonald, Hassan El-Saidi, Carolynne Ricardo, Bhumi Bhatt, Jack Moore, Diana Diaz-Dussan, Nirilanto Ramamonjisoa, Yvonne Mowery, Sambasivarao Damaraju, Richard Fahlman, Piyush Kumar, Michael Weinfeld
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Redox Biology
Subjects:
Hypoxia
Nitroimidazole
Click chemistry
Head and neck tumour
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000537

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http://www.sciencedirect.com/science/article/pii/S2213231721000537

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