Neuroprotection in early stages of Alzheimer’s disease is promoted by transthyretin angiogenic properties

Neuroprotection in early stages of Alzheimer’s disease is promoted by transthyretin angiogenic properties

Abstract Background While still controversial, it has been demonstrated that vascular defects can precede the onset of other AD hallmarks features, making it an important therapeutic target. Given that the protein transthyretin (TTR) has been established as neuroprotective in AD, here we investigate...

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Bibliographic Details
Main Authors: Tiago Gião, Joana Saavedra, José Ricardo Vieira, Marta Teixeira Pinto, Gemma Arsequell, Isabel Cardoso
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Transthyretin
Alzheimer’s disease
Basement membrane
Angiogenesis
Neuroprotection
TTR tetramer stabilizers
Online Access:https://doi.org/10.1186/s13195-021-00883-8

Internet

https://doi.org/10.1186/s13195-021-00883-8

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