The Mycobacterium tuberculosis MmpL3 inhibitor MSU-43085 is active in a mouse model of infection

The Mycobacterium tuberculosis MmpL3 inhibitor MSU-43085 is active in a mouse model of infection

ABSTRACT Addressing drug resistance in Mycobacterium tuberculosis (Mtb) requires the development of new drugs with new targets. We previously identified 13 MmpL3 inhibitors from a screen of a small library of Mtb growth inhibitors. In this report, we describe the biological activities of a set of HC...

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Bibliographic Details
Main Authors: John T. Williams, Matthew Giletto, Elizabeth R. Haiderer, Bilal Aleiwi, Teresa Krieger-Burke, Edmund Ellsworth, Robert B. Abramovitch
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium tuberculosis
nontuberculous mycobacteria
drug development
MmpL3
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03677-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03677-23

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