Decoding the Role of Melatonin Structure on <i>Plasmodium falciparum</i> Human Malaria Parasites Synchronization Using 2-Sulfenylindoles Derivatives

Decoding the Role of Melatonin Structure on <i>Plasmodium falciparum</i> Human Malaria Parasites Synchronization Using 2-Sulfenylindoles Derivatives

Melatonin acts to synchronize the parasite’s intraerythrocytic cycle by triggering the phospholipase <i>C</i>-inositol 1,4,5-trisphosphate (PLC-IP<sub>3</sub>) signaling cascade. Compounds with an indole scaffold impair in vitro proliferation of blood-stage malaria parasites,...

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Bibliographic Details
Main Authors: Lenna Rosanie Cordero Mallaupoma, Bárbara Karina de Menezes Dias, Maneesh Kumar Singh, Rute Isabel Honorio, Myna Nakabashi, Camila de Menezes Kisukuri, Márcio Weber Paixão, Celia R. S. Garcia
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomolecules
Subjects:
antimalarial
2-sulfenylindoles
melatonin
<i>Plasmodium falciparum</i>
chloroquine-resistant parasites
Online Access:https://www.mdpi.com/2218-273X/12/5/638

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https://www.mdpi.com/2218-273X/12/5/638

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