A semi-compartmental model describing the pharmacokinetic-pharmacodynamic relationship
Frequently, we encounter the phenomenon of hysteresis in kinetic-dynamic modeling. The hysteresis loop in the concentration-effect curve suggests a time discrepancy caused by various pharmacokinetic and pharmacodynamic factors. To collapse the hysteresis loop and to simplify the concentration-effect...
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2020-01-01
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| Series: | Anesthesia and Pain Medicine |
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| Online Access: | http://www.anesth-pain-med.org/upload/pdf/APM-15-001.pdf |