Blockade of IL-18Rα-mediated signaling pathway exacerbates neutrophil infiltration in imiquimod-induced psoriasis murine model

Blockade of IL-18Rα-mediated signaling pathway exacerbates neutrophil infiltration in imiquimod-induced psoriasis murine model

Psoriasis is an immune-mediated inflammatory disease of the skin, which is characterized by epidermal hyperkeratosis and neutrophil infiltration. The interleukin (IL)-17/IL-23 pathway and associated cytokines play major roles in the pathogenesis and exacerbation of psoriasis. The IL-18/IL-18 recepto...

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Bibliographic Details
Main Authors: Hiroki Akazawa, Yuji Nozaki, Hirotaka Yamazawa, Kaori Ishimura, Chisato Ashida, Akinori Okada, Koji Kinoshita, Itaru Matsumura
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Medicine
Subjects:
immune-mediated inflammatory disease
psoriasis
IL-18Rα
neutrophil
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1293132/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1293132/full

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