Seizure-Induced Potentiation of AMPA Receptor-Mediated Synaptic Transmission in the Entorhinal Cortex

Seizure-Induced Potentiation of AMPA Receptor-Mediated Synaptic Transmission in the Entorhinal Cortex

Excessive excitation is considered one of the key mechanisms underlying epileptic seizures. We investigated changes in the evoked postsynaptic responses of medial entorhinal cortex (ERC) pyramidal neurons by seizure-like events (SLEs), using the modified 4-aminopyridine (4-AP) model of epileptiform...

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Bibliographic Details
Main Authors: Dmitry V. Amakhin, Elena B. Soboleva, Julia L. Ergina, Sergey L. Malkin, Anton V. Chizhov, Aleksey V. Zaitsev
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
temporal lobe epilepsy
calcium-permeable AMPA receptor
epileptiform activity
entorhinal cortex
seizure-like event
synaptic plasticity
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00486/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00486/full

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