The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.

The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.

We recently published that the positive inotropic response (PIR) to levosimendan can be fully accounted for by phosphodiesterase (PDE) inhibition in both failing human heart and normal rat heart. To determine if the PIR of the active metabolite OR-1896, an important mediator of the long-term clinica...

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Bibliographic Details
Main Authors: Øivind Ørstavik, Ornella Manfra, Kjetil Wessel Andressen, Geir Øystein Andersen, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy, Kurt Allen Krobert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4349697?pdf=render

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http://europepmc.org/articles/PMC4349697?pdf=render

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