Genetic and Epigenetic Mechanisms Deregulate the CRL2pVHL Complex in Hepatocellular Carcinoma

Genetic and Epigenetic Mechanisms Deregulate the CRL2pVHL Complex in Hepatocellular Carcinoma

Dysregulation of ubiquitin-proteasome pathway genes through copy number alteration, promoter hypomethylation, and miRNA deregulation is involved in cancer development and progression. Further characterizing alterations in these genes may uncover novel drug targets across a range of diseases in which...

Full description

Bibliographic Details
Main Authors: Brenda C. Minatel, David E. Cohn, Michelle E. Pewarchuk, Mateus C. Barros-Filho, Adam P. Sage, Greg L. Stewart, Erin A. Marshall, Nikita Telkar, Victor D. Martinez, Patricia P. Reis, Wendy P. Robinson, Wan L. Lam
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Genetics
Subjects:
liver cancer
ubiquitin-proteasome
novel microRNAs
DNA copy number
DNA hypomethylation
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.910221/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.910221/full

Similar Items