Muc2 mucin o-glycosylation interacts with enteropathogenic Escherichia coli to influence the development of ulcerative colitis based on the NF-kB signaling pathway

Muc2 mucin o-glycosylation interacts with enteropathogenic Escherichia coli to influence the development of ulcerative colitis based on the NF-kB signaling pathway

Abstract Background Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine characterized by a compromised intestinal epithelial barrier. Mucin glycans are crucial in preserving barrier function during bacterial infections, although the underlying mechanisms remain largely unexplo...

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Bibliographic Details
Main Authors: Juan Wei, Chunyan Chen, Jing Feng, Shuping Zhou, Xiaoyue Feng, Zhao Yang, Heng Lu, Hui Tao, Liuying Li, Huabing Xv, Ji Xuan, Fangyu Wang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
Ulcerative colitis
Intestinal epithelium
o-glycan
Escherichia coli
Intestinal epithelial barrier
Gut microbiota
Online Access:https://doi.org/10.1186/s12967-023-04687-2

Internet

https://doi.org/10.1186/s12967-023-04687-2

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