Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire
Vast repertoires of unique antigen receptors are created in developing B and T lymphocytes. The antigen receptor loci contain many variable (V), diversity (D) and joining (J) gene segments that are arrayed across very large genomic expanses and are joined to form variable-region exons of expressed i...
Main Authors: | , , |
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Format: | Article |
Jezik: | English |
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Frontiers Media S.A.
2021-05-01
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Serija: | Frontiers in Immunology |
Teme: | |
Online dostop: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.682589/full |