Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire

Vast repertoires of unique antigen receptors are created in developing B and T lymphocytes. The antigen receptor loci contain many variable (V), diversity (D) and joining (J) gene segments that are arrayed across very large genomic expanses and are joined to form variable-region exons of expressed i...

Popoln opis

Bibliografske podrobnosti
Main Authors: Amy L. Kenter, Corey T. Watson, Jan-Hendrik Spille
Format: Article
Jezik:English
Izdano: Frontiers Media S.A. 2021-05-01
Serija:Frontiers in Immunology
Teme:
Online dostop:https://www.frontiersin.org/articles/10.3389/fimmu.2021.682589/full