Integrated spatial analysis of gene mutation and gene expression for understanding tumor diversity in formalin-fixed paraffin-embedded lung adenocarcinoma

Integrated spatial analysis of gene mutation and gene expression for understanding tumor diversity in formalin-fixed paraffin-embedded lung adenocarcinoma

IntroductionA deeper understanding of intratumoral heterogeneity is essential for prognosis prediction or accurate treatment plan decisions in clinical practice. However, due to the cross-links and degradation of biomolecules within formalin-fixed paraffin-embedded (FFPE) specimens, it is challengin...

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Bibliographic Details
Main Authors: Miki Yamazaki, Masahito Hosokawa, Hiroko Matsunaga, Koji Arikawa, Kazuya Takamochi, Kenji Suzuki, Takuo Hayashi, Hideki Kambara, Haruko Takeyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
spatial transcriptome
non-small cell lung cancer (NSCLC)
tyrosine-kinase inhibitors (TKIs)
drug resistance
formalin-fixed paraffin-embedded specimens
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.936190/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.936190/full

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