Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

Pancreatic ductal adenocarcinoma (PDAC) continues to show no improvement in survival rates. One aspect of PDAC is elevated ATP levels, pointing to the purinergic axis as a potential attractive therapeutic target. Mediated in part by highly druggable extracellular proteins, this axis plays essential...

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Bibliographic Details
Main Authors: Elena Tomas Bort, Megan D Joseph, Qiaoying Wang, Edward P Carter, Nicolas J Roth, Jessica Gibson, Ariana Samadi, Hemant M Kocher, Sabrina Simoncelli, Peter J McCormick, Richard P Grose
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
pancreatic cancer
purinergic signalling
invasion
DNA-PAINT
3D modelling
Online Access:https://elifesciences.org/articles/86971

Internet

https://elifesciences.org/articles/86971

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