Quantitative Phosphoproteomics Reveals the Requirement of DYRK1-Mediated Phosphorylation of Ion Transport- and Cell Junction-Related Proteins for Notochord Lumenogenesis in Ascidian

Quantitative Phosphoproteomics Reveals the Requirement of DYRK1-Mediated Phosphorylation of Ion Transport- and Cell Junction-Related Proteins for Notochord Lumenogenesis in Ascidian

The dual-specificity tyrosine phosphorylation-regulated kinase (DYRK1) phosphorylates diverse substrates involved in various cellular processes. Here, we found that blocking the kinase activity of DYRK1 inhibited notochord development and lumenogenesis in ascidian <i>Ciona savignyi</i>....

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Bibliographic Details
Main Authors: Zhuqing Wang, Xiuke Ouyang, Zicheng Tan, Likun Yang, Bo Dong
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
<i>Ciona</i> notochord
phosphoproteomics
proteomics
lumen expansion
vesicle trafficking
transmembrane transport
Online Access:https://www.mdpi.com/2073-4409/12/6/921

Internet

https://www.mdpi.com/2073-4409/12/6/921

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