Reduced oxidative stress suppresses neurotoxicity in the Drosophila model of TAF15-associated proteinopathies

Reduced oxidative stress suppresses neurotoxicity in the Drosophila model of TAF15-associated proteinopathies

Abstract TATA-binding protein associated factor 15 (TAF15) is involved in the pathology of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although TAF15 accumulates as cytoplasmic aggregates in neurons and the clearance of aggregates may be a therapeutic strategy for ALS, the...

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Bibliographic Details
Main Authors: Yeo Jeong Han, Kiyoung Kim
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Brain
Subjects:
Drosophila
Oxidative stress
Proteinopathies
Glutathione transferase
TAF15
Neurodegenerative disease
Online Access:https://doi.org/10.1186/s13041-022-00979-8

Internet

https://doi.org/10.1186/s13041-022-00979-8

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