Nimbolide-based nanomedicine inhibits breast cancer stem-like cells by epigenetic reprogramming of DNMTs-SFRP1-Wnt/β-catenin signaling axis

Nimbolide-based nanomedicine inhibits breast cancer stem-like cells by epigenetic reprogramming of DNMTs-SFRP1-Wnt/β-catenin signaling axis

Triple-negative breast cancer (TNBC) harbors a high percentage of breast cancer stem-like cells (BCSCs) that significantly contribute to poor prognosis, metastasis, and relapse of the disease. Thus, targeting BCSCs could be a promising approach to combat TNBC. In this context, we investigated nimbol...

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Bibliographic Details
Main Authors: Priyanka Mohapatra, Swati Madhulika, Somalisa Behera, Priya Singh, Pratikshya Sa, Punit Prasad, Rajeeb Kumar Swain, Sanjeeb Kumar Sahoo
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
triple-negative breast cancer
cancer stem cells
nanomedicine
nimbolide
epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002445

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http://www.sciencedirect.com/science/article/pii/S2162253123002445

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