In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents

Abstract Sirtuin 2 (SIRT2) is a member of the sirtuin protein family, which includes lysine deacylases that are NAD+-dependent and organize several biological processes. Different forms of cancer have been associated with dysregulation of SIRT2 activity. Hence, identifying potent inhibitors for SIRT...

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Bibliographic Details
Main Authors: Mahmoud A. A. Ibrahim, Khlood A. A. Abdeljawaad, Eslam Roshdy, Dina E. M. Mohamed, Taha F. S. Ali, Gamal A. Gabr, Laila A. Jaragh-Alhadad, Gamal A. H. Mekhemer, Ahmed M. Shawky, Peter A. Sidhom, Alaa H. M. Abdelrahman
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28226-7