Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL).

Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL).

Pancreatic ductal adenocarcinoma (PDAC) presents at advanced stages and is refractory to most treatment modalities. Wnt signaling activation plays a critical role in proliferation and chemotherapeutic resistance. Minimal media conditions, growth factor dependency, and Wnt dependency were determined...

Full description

Bibliographic Details
Main Authors: Hayley J Hawkins, Betelehem W Yacob, Monica E Brown, Brandon R Goldstein, John J Arcaroli, Stacey M Bagby, Sarah J Hartman, Morgan Macbeth, Andrew Goodspeed, Thomas Danhorn, Robert W Lentz, Christopher H Lieu, Alexis D Leal, Wells A Messersmith, Peter J Dempsey, Todd M Pitts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298808&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298808&type=printable

Similar Items