Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL).

Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL).

Pancreatic ductal adenocarcinoma (PDAC) presents at advanced stages and is refractory to most treatment modalities. Wnt signaling activation plays a critical role in proliferation and chemotherapeutic resistance. Minimal media conditions, growth factor dependency, and Wnt dependency were determined...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Hayley J Hawkins, Betelehem W Yacob, Monica E Brown, Brandon R Goldstein, John J Arcaroli, Stacey M Bagby, Sarah J Hartman, Morgan Macbeth, Andrew Goodspeed, Thomas Danhorn, Robert W Lentz, Christopher H Lieu, Alexis D Leal, Wells A Messersmith, Peter J Dempsey, Todd M Pitts
Format: Artykuł
Język:English
Wydane: Public Library of Science (PLoS) 2024-01-01
Seria:PLoS ONE
Dostęp online:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298808&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298808&type=printable

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