Basket to Purkinje Cell Inhibitory Ephaptic Coupling Is Abolished in Episodic Ataxia Type 1

Dominantly inherited missense mutations of the <i>KCNA1</i> gene, which encodes the K<sub>V</sub>1.1 potassium channel subunit, cause Episodic Ataxia type 1 (EA1). Although the cerebellar incoordination is thought to arise from abnormal Purkinje cell output, the underlying fu...

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Bibliographic Details
Main Authors: Henry G. S. Martin, Dimitri M. Kullmann
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/12/10/1382