Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism

Aim: Isocitrate dehydrogenase 1 (IDH1) is key enzyme involved in cellular metabolism and DNA repair. Mutations in IDH1 occur in up to 25% of cholangiocarcinomas. The present study aimed to explore the features of cellosaurus REB cells with mutant and wide-type IDH1.Methods: To compare the features o...

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Bibliographic Details
Main Authors: Li Su, Xinglong Zhang, Lei Zheng, Miaomiao Wang, Zhifa Zhu, Ping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Endocrinology
Subjects:
cholangiocarcinoma
isocitrate dehydrogenase 1
aldehyde dehydrogenase 1
α-ketoglutarate
NADPH
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00189/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00189/full

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