Dorsal root ganglion inflammation by oxaliplatin toxicity: DPEP1 as possible target for peripheral neuropathy prevention

Dorsal root ganglion inflammation by oxaliplatin toxicity: DPEP1 as possible target for peripheral neuropathy prevention

Abstract Background Peripheral neuropathy (PN) constitutes a dose-limiting side effect of oxaliplatin chemotherapy that often compromises the efficacy of antineoplastic treatments. Sensory neurons damage in dorsal root ganglia (DRG) are the cellular substrate of PN complex molecular origin. Dehydrop...

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Bibliographic Details
Main Authors: Karen Álvarez-Tosco, Rebeca González-Fernández, María Ángeles González-Nicolás, Rita Martín-Ramírez, Manuel Morales, Ricardo Gutiérrez, Lucio Díaz-Flores, María Rosa Arnau, Félix Machín, Julio Ávila, Alberto Lázaro, Pablo Martín-Vasallo
Format: Article
Language:English
Published: BMC 2024-09-01
Series:BMC Neuroscience
Subjects:
Dorsal root ganglion (DRG)
Oxaliplatin
Neurotoxicity
DRG-inflammation
Dehydropeptidase-1 (DPEP1)
Allodynia
Online Access:https://doi.org/10.1186/s12868-024-00891-y

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https://doi.org/10.1186/s12868-024-00891-y

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