TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells

TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells

The TGF-β and Hippo pathways are critical for liver size control, regeneration, and cancer progression. The transcriptional cofactor TAZ, also named WWTR1, is a downstream effector of Hippo pathway and plays a key role in the maintenance of liver physiological functions. However, the up-regulation o...

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Bibliographic Details
Main Authors: Diana G. Ríos-López, Angeles C. Tecalco-Cruz, David Martínez-Pastor, Marcela Sosa-Garrocho, Gustavo Tapia-Urzúa, Yuli Aranda-López, Bibiana Ortega-Domínguez, Félix Recillas-Targa, Genaro Vázquez-Victorio, Marina Macías-Silva
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
TGF-β cytokine
Hippo-pathway
TAZ cofactor
HepG2 cells
Liver cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023087273

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http://www.sciencedirect.com/science/article/pii/S2405844023087273

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