TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
The TGF-β and Hippo pathways are critical for liver size control, regeneration, and cancer progression. The transcriptional cofactor TAZ, also named WWTR1, is a downstream effector of Hippo pathway and plays a key role in the maintenance of liver physiological functions. However, the up-regulation o...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023087273 |
| _version_ | 1797429867231313920 |
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| author | Diana G. Ríos-López Angeles C. Tecalco-Cruz David Martínez-Pastor Marcela Sosa-Garrocho Gustavo Tapia-Urzúa Yuli Aranda-López Bibiana Ortega-Domínguez Félix Recillas-Targa Genaro Vázquez-Victorio Marina Macías-Silva |
| author_facet | Diana G. Ríos-López Angeles C. Tecalco-Cruz David Martínez-Pastor Marcela Sosa-Garrocho Gustavo Tapia-Urzúa Yuli Aranda-López Bibiana Ortega-Domínguez Félix Recillas-Targa Genaro Vázquez-Victorio Marina Macías-Silva |
| author_sort | Diana G. Ríos-López |
| collection | DOAJ |
| description | The TGF-β and Hippo pathways are critical for liver size control, regeneration, and cancer progression. The transcriptional cofactor TAZ, also named WWTR1, is a downstream effector of Hippo pathway and plays a key role in the maintenance of liver physiological functions. However, the up-regulation of TAZ expression has been associated with liver cancer progression. Recent evidence shows crosstalk of TGF-β and Hippo pathways, since TGF-β modulates TAZ expression through different mechanisms in a cellular context-dependent manner but supposedly independent of SMADs. Here, we evaluate the molecular interplay between TGF-β pathway and TAZ expression and observe that TGF-β induces TAZ expression through SMAD canonical pathway in liver cancer HepG2 cells. Therefore, TAZ cofactor is a primary target of TGF-β/SMAD-signaling, one of the pathways altered in liver cancer. |
| first_indexed | 2024-03-09T09:19:08Z |
| format | Article |
| id | doaj.art-ad00e525b770493ca6f0623c00db2fff |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:19:08Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ad00e525b770493ca6f0623c00db2fff2023-12-02T07:02:38ZengElsevierHeliyon2405-84402023-11-01911e21519TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cellsDiana G. Ríos-López0Angeles C. Tecalco-Cruz1David Martínez-Pastor2Marcela Sosa-Garrocho3Gustavo Tapia-Urzúa4Yuli Aranda-López5Bibiana Ortega-Domínguez6Félix Recillas-Targa7Genaro Vázquez-Victorio8Marina Macías-Silva9Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoPrograma en Ciencias Genómicas, Universidad Autónoma de La Ciudad de México, Ciudad de México 03100, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoFacultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico; Corresponding author. Instituto de Fisiología Celular, UNAM. Ciudad Universitaria, Coyoacán, Ciudad de México 04510, Mexico.The TGF-β and Hippo pathways are critical for liver size control, regeneration, and cancer progression. The transcriptional cofactor TAZ, also named WWTR1, is a downstream effector of Hippo pathway and plays a key role in the maintenance of liver physiological functions. However, the up-regulation of TAZ expression has been associated with liver cancer progression. Recent evidence shows crosstalk of TGF-β and Hippo pathways, since TGF-β modulates TAZ expression through different mechanisms in a cellular context-dependent manner but supposedly independent of SMADs. Here, we evaluate the molecular interplay between TGF-β pathway and TAZ expression and observe that TGF-β induces TAZ expression through SMAD canonical pathway in liver cancer HepG2 cells. Therefore, TAZ cofactor is a primary target of TGF-β/SMAD-signaling, one of the pathways altered in liver cancer.http://www.sciencedirect.com/science/article/pii/S2405844023087273TGF-β cytokineHippo-pathwayTAZ cofactorHepG2 cellsLiver cancer |
| spellingShingle | Diana G. Ríos-López Angeles C. Tecalco-Cruz David Martínez-Pastor Marcela Sosa-Garrocho Gustavo Tapia-Urzúa Yuli Aranda-López Bibiana Ortega-Domínguez Félix Recillas-Targa Genaro Vázquez-Victorio Marina Macías-Silva TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells Heliyon TGF-β cytokine Hippo-pathway TAZ cofactor HepG2 cells Liver cancer |
| title | TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells |
| title_full | TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells |
| title_fullStr | TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells |
| title_full_unstemmed | TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells |
| title_short | TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells |
| title_sort | tgf β smad canonical pathway induces the expression of transcriptional cofactor taz in liver cancer cells |
| topic | TGF-β cytokine Hippo-pathway TAZ cofactor HepG2 cells Liver cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023087273 |
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