Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor

Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor

The HIF-1 and HIF-2 (HIF1/2) hypoxia responses are frequently upregulated in cancers, and HIF1/2 inhibitors are being developed as anticancer drugs. How could cancers resist anti-HIF1/2 therapy? We studied metabolic and molecular adaptations of HIF-1β-deficient Hepa-1c4, a hepatoma model lacking HIF...

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Bibliographic Details
Main Authors: Monika A. Golinska, Marion Stubbs, Adrian L. Harris, Laszlo G. Boros, Madhu Basetti, Dominick J. O. McIntyre, John R. Griffiths
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
HIF-1β deficiency
Hepa-1 c4 cells
hypoxia response
1,2-<sup>13</sup>C<sub>2</sub>-labelled glucose
TCA
fatty acid oxidation
Online Access:https://www.mdpi.com/2073-4409/11/22/3595

Internet

https://www.mdpi.com/2073-4409/11/22/3595

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