Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse

Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse

Duchenne muscular dystrophy (DMD) is caused by the absence of dystrophin, a protein that fulfills important functions in both muscle and brain. The mdx mouse model of DMD, which also lacks dystrophin, shows a marked reduction in γ-aminobutyric acid type A (GABAA)-receptor clustering in central inhib...

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Bibliographic Details
Main Authors: Glenn Dallérac, Caroline Perronnet, Carine Chagneau, Pascale Leblanc-Veyrac, Nathalie Samson-Desvignes, Elise Peltekian, Olivier Danos, Luis Garcia, Serge Laroche, Jean-Marie Billard, Cyrille Vaillend
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Neurobiology of Disease
Subjects:
Dystrophin
Exon skipping
Gene therapy
Mdx mouse
Synaptic plasticity
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001689

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http://www.sciencedirect.com/science/article/pii/S0969996111001689

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