Development and validation of a UPLC-MS/MS method for simultaneous detection of doxorubicin and sorafenib in plasma: Application to pharmacokinetic studies in rats

Development and validation of a UPLC-MS/MS method for simultaneous detection of doxorubicin and sorafenib in plasma: Application to pharmacokinetic studies in rats

An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for the simultaneous quantitation of doxorubicin (DOX) and sorafenib (SOR) in rat plasma. Chromatographic separation was performed using a reversed-phase column C18 (1.7 μm, 1.0 × 100 mm Acquity UPLC BEH™)...

Full description

Bibliographic Details
Main Authors: Alanoud Altalal, Aliyah Almomen, Musaed Alkholief, Ziyad Binkhathlan, Nourah Z. Alzoman, Aws Alshamsan
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Saudi Pharmaceutical Journal
Subjects:
Doxorubicin
Sorafenib
Co-administration
UPLC-MS/MS
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423001512

Internet

http://www.sciencedirect.com/science/article/pii/S1319016423001512

Similar Items