Development and validation of a UPLC-MS/MS method for simultaneous detection of doxorubicin and sorafenib in plasma: Application to pharmacokinetic studies in rats

Development and validation of a UPLC-MS/MS method for simultaneous detection of doxorubicin and sorafenib in plasma: Application to pharmacokinetic studies in rats

An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for the simultaneous quantitation of doxorubicin (DOX) and sorafenib (SOR) in rat plasma. Chromatographic separation was performed using a reversed-phase column C18 (1.7 μm, 1.0 × 100 mm Acquity UPLC BEH™)...

Full description

Bibliographic Details
Main Authors:	Alanoud Altalal, Aliyah Almomen, Musaed Alkholief, Ziyad Binkhathlan, Nourah Z. Alzoman, Aws Alshamsan
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Series:	Saudi Pharmaceutical Journal
Subjects:	Doxorubicin Sorafenib Co-administration UPLC-MS/MS Pharmacokinetics
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319016423001512

Similar Items

Development of UPLC-MS/MS Method to Study the Pharmacokinetic Interaction between Sorafenib and Dapagliflozin in Rats
by: Xueru He, et al.
Published: (2022-09-01)

Development and Validation of UPLC–MS/MS Method for Quantitative Analysis of 5-Fluorouracil in Aqueous Humor of Rabbits
by: Mohd Abul Kalam, et al.
Published: (2023-06-01)

Simultaneous Quantification of a Neoadjuvant Treatment Used in Locally Advanced Breast Cancer Using an Eco-Friendly UPLC-MS/MS Method: A Pharmacokinetic Study in Rat Plasma
by: Noha F. El Azab, et al.
Published: (2022-12-01)

Determination of oleandrin and adynerin in rat plasma by UPLC–MS/MS and their pharmacokinetic study
by: Meiling Zhang, et al.
Published: (2022-12-01)

Development of an UPLC-MS/MS method for quantitative analysis of abexinostat levels in rat plasma and application of pharmacokinetics
by: Yige Yu, et al.
Published: (2024-02-01)

UPLC–MS/MS for the determination of azilsartan in beagle dog plasma and its application in a pharmacokinetics study
by: Cheng Gong, et al.
Published: (2015-06-01)

Determination of Aflatoxins in Grains by QuEChERS-UPLC-MS/MS
by: WU Qin-yan, et al.
Published: (2024-03-01)

Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats
by: Yang S, et al.
Published: (2021-05-01)

Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS
by: Ming Li, et al.
Published: (2022-07-01)

Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study
by: Li S, et al.
Published: (2020-03-01)

An Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC–MS/MS) Method for Qualifying DAPB in Rat Plasma and Application to Pharmacokinetic Studies
by: Bei Qin, et al.
Published: (2024-01-01)

Pharmacokinetics of Herb-Drug Interactions of Plumbagin and Tazemetostat in Rats by UPLC-MS/MS
by: Li H, et al.
Published: (2022-09-01)

Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS
by: Vanessa de Jesus Gaffney, et al.
Published: (2014-01-01)

Validation of UPLC-MS/MS Method for Determination of Urinary Lactulose/Mannitol
by: Jacopo Gervasoni, et al.
Published: (2018-10-01)

Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies
by: Mengchun Chen, et al.
Published: (2020-04-01)

Pharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS
by: Lei P, et al.
Published: (2024-01-01)

Pharmacokinetics of niazirin from Moringa oleifera Lam in rats by UPLC‐MS/MS: Absolute bioavailability and dose proportionality
by: Fang Wang, et al.
Published: (2022-12-01)

Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study
by: Wang MJ, et al.
Published: (2021-10-01)

Quantitative Analysis of Eight Compounds in Traditional Korean Medicine, Gongjindan Using HPLC, UPLC–MS/MS, and GC–MS/MS Systems
by: Chang-Seob Seo, et al.
Published: (2023-03-01)

The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique
by: Wang H, et al.
Published: (2021-11-01)

SPE–UPLC–MS/MS for Determination of 36 Monomers of Alkylphenol Ethoxylates in Tea
by: Qin Lin, et al.
Published: (2023-04-01)

Multi-Residue Analysis of Pesticide Residues in Crude Pollens by UPLC-MS/MS
by: Zhou Tong, et al.
Published: (2016-12-01)

UPLC-MS/MS quantification of quercetin in plasma and urine following parenteral administration
by: Igor A. Zupanets, et al.
Published: (2019-01-01)

Eco-Friendly UPLC–MS/MS Method for Determination of a Fostamatinib Metabolite, Tamatinib, in Plasma: Pharmacokinetic Application in Rats
by: Essam Ezzeldin, et al.
Published: (2021-07-01)

Analytical methodology and pharmacokinetic study of elagolix in plasma of rats using a newly developed UPLC-MS/MS assay
by: Qiong Wang, et al.
Published: (2021-07-01)

A high throughput method for Monitoring of Sorafenib, regorafenib, cabozantinib and their metabolites with UPLC-MS/MS in rat plasma
by: Er-Min Gu, et al.
Published: (2022-09-01)

Establishment of a sensitive UPLC-MS/MS method to quantify safinamide in rat plasma
by: Ying Wang, et al.
Published: (2023-08-01)

Establishment and validation of a UPLC-MS/MS bioassay for the quantification of infigratinib in rat plasma
by: Xuegu Xu, et al.
Published: (2022-07-01)

Validation of Pesticides Multi-Residual Testing Method on Nutmeg by Using UPLC-MS/MS
by: Bayu Refindra Fitriadi
Published: (2021-12-01)

Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS
by: Xinyi Wei, et al.
Published: (2024-02-01)

The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique [Corrigendum]
by: Wang H, et al.
Published: (2023-11-01)

Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug–Drug Interactions of Selinexor with Posaconazole in Rats
by: Zhou C, et al.
Published: (2021-04-01)

Simultaneous determination of amiodarone, dronedarone, and their principal metabolites in SD rat plasma by UPLC-MS/MS and its application in pharmacokinetics
by: Ying Zhang, et al.
Published: (2021-08-01)

Simultaneous determination of tofacitinib and its principal metabolite in beagle dog plasma by UPLC-MS/MS and its application in pharmacokinetics
by: Qiong Wang, et al.
Published: (2022-01-01)

An UPLC-MS/MS method to monitor Estriol injection and comparison of pharmacokinetic characteristics after irradiation
by: Hanming Zhang, et al.
Published: (2021-06-01)

Development of a Proton-Enhanced ESI UPLC-MS/MS Method for the Determination of Tetrodotoxin
by: Tong Li, et al.
Published: (2022-12-01)

Development of an UPLC-MS/MS Method for Quantitative Analysis of Clotrimazole in Human Plasma Samples
by: Lucia Lisi, et al.
Published: (2020-11-01)

A pharmacokinetic study on twenty-one compounds in rat plasma by integrating UPLC-QQQ-MS/MS with GC-MS after oral administration of Suxiao Jiuxin pill
by: Ye Shang, et al.
Published: (2024-01-01)

Investigation of preclinical pharmacokinetics of N-demethylsinomenine, a potential novel analgesic candidate, using an UPLC-MS/MS quantification method
by: Lulu Yu, et al.
Published: (2023-07-01)

UPLC-MS/MS Measurement of the Effect of Isavuconazole, Itraconazole and Fluconazole on the Pharmacokinetics of Selinexor in Rats
by: Li S, et al.
Published: (2020-09-01)