Overexpression of bHLH domain of HIF-1 failed to inhibit the HIF-1 transcriptional activity in hypoxia

Overexpression of bHLH domain of HIF-1 failed to inhibit the HIF-1 transcriptional activity in hypoxia

Abstract Background Hypoxia inducible factor-1 (HIF-1) is considered as the most activated transcriptional factor in response to low oxygen level or hypoxia. HIF-1 binds the hypoxia response element (HRE) sequence in the promoter of different genes, mainly through the bHLH domain and activates the t...

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Bibliographic Details
Main Authors: Fatemeh Sadeghi, Gholam Ali Kardar, Mohammad Reza Bolouri, Farzad Nasri, Maryam Sadri, Reza Falak
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Biological Research
Subjects:
Cancer
Hypoxia
HIF-1
Arnt
bHLH
PAS
Online Access:http://link.springer.com/article/10.1186/s40659-020-00293-4

Internet

http://link.springer.com/article/10.1186/s40659-020-00293-4

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