Identification of let-7f and miR-338 as plasma-based biomarkers for sporadic amyotrophic lateral sclerosis using meta-analysis and empirical validation

Abstract Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease that in most cases occurs sporadic (sALS). The disease is not curable, and its pathogenesis mechanisms are not well understood yet. Given the intricacy of underlying molecular interactions and heterogeneity of ALS, th...

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Bibliographic Details
Main Authors: Narges Daneshafrooz, Mohammad Taghi Joghataei, Mehdi Mehdizadeh, Afagh Alavi, Mahmood Barati, Bahman Panahi, Shahram Teimourian, Babak Zamani
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05067-4