STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

Abstract In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human tau accumulation activated Signal Transduction and Activator of Transcription-1 (ST...

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Main Authors: Xiao-Yue Hong, Hua-Li Wan, Ting Li, Bing-Ge Zhang, Xiao-Guang Li, Xin Wang, Xiao Li, Qian Liu, Chong-Yang Chen, Ying Yang, Qun Wang, Shu-Peng Li, Hao Yu, Jian-Zhi Wang, Xi-Fei Yang, Gong-Ping Liu
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-020-00290-9

Internet

https://doi.org/10.1038/s41392-020-00290-9

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