STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

Abstract In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human tau accumulation activated Signal Transduction and Activator of Transcription-1 (ST...

Full description

Bibliographic Details
Main Authors:	Xiao-Yue Hong, Hua-Li Wan, Ting Li, Bing-Ge Zhang, Xiao-Guang Li, Xin Wang, Xiao Li, Qian Liu, Chong-Yang Chen, Ying Yang, Qun Wang, Shu-Peng Li, Hao Yu, Jian-Zhi Wang, Xi-Fei Yang, Gong-Ping Liu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-12-01
Series:	Signal Transduction and Targeted Therapy
Online Access:	https://doi.org/10.1038/s41392-020-00290-9

Similar Items

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
by: Pickering-Brown Stuart, et al.
Published: (2006-08-01)

VALIDATION OF THERAPEUTIC SIRNAS IN HIPSC-DERIVED FTDP-17 NEURONAL MODEL OF TAUOPATHY
by: Ilaria Brentari, et al.
Published: (2023-10-01)

Behavioral and Neuropathological Phenotyping of the Tau58/2 and Tau58/4 Transgenic Mouse Models for FTDP-17
by: Debby Van Dam, et al.
Published: (2023-10-01)

Role of α7nAChR-NMDAR in sevoflurane-induced memory deficits in the developing rat hippocampus.
by: XiaoHong Tang, et al.
Published: (2018-01-01)

An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia
by: Ryohei Watanabe, et al.
Published: (2021-09-01)

Concurrent Tuberculous Meningoencephalitis and Anti-NMDAR Encephalitis: A Case Report
by: Chen Xiaoli, et al.
Published: (2022-07-01)

The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells
by: Cristina Di Primio, et al.
Published: (2017-06-01)

Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus
by: Chao Zhang, et al.
Published: (2018-09-01)

Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau
by: Zhang Xue, et al.
Published: (2006-07-01)

Corrigendum: Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus
by: Chao Zhang, et al.
Published: (2018-10-01)

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes
by: An Verheyen, et al.
Published: (2018-08-01)

Neuronal NMDAR Currents of the Hippocampus and Learning Performance in Autoimmune Anti-NMDAR Encephalitis and Involvement of TNF-α and IL-6
by: Xu Wang, et al.
Published: (2019-06-01)

Piperine ameliorates SCA17 neuropathology by reducing ER stress
by: Jifeng Guo, et al.
Published: (2018-01-01)

Knockdown of pp32 Increases Histone Acetylation and Ameliorates Cognitive Deficits
by: Gong-Ping Liu, et al.
Published: (2017-04-01)

Anti-NMDAR antibodies, the blood–brain barrier, and anti-NMDAR encephalitis
by: Xiarong Gong, et al.
Published: (2023-12-01)

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration
by: Noemí Esteras, et al.
Published: (2017-08-01)

GluN2B-containing NMDARs in the mammalian brain: pharmacology, physiology, and pathology
by: Yang Ge, et al.
Published: (2023-05-01)

Efficacy and Safety of Rituximab in Chinese Children With Refractory Anti-NMDAR Encephalitis
by: Xiangjun Dou, et al.
Published: (2020-12-01)

Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling
by: Jiejie Zhao, et al.
Published: (2018-07-01)

NMDARs antagonist MK801 suppresses LPS-induced apoptosis and mitochondrial dysfunction by regulating subunits of NMDARs via the CaM/CaMKII/ERK pathway
by: Wei-Min Han, et al.
Published: (2023-02-01)

Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation
by: Luye Qin, et al.
Published: (2019-07-01)

Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating
by: Shi-Ning Deng, et al.
Published: (2019-02-01)

Contribution of p38 MAPK to the Ameliorating Effect of Enriched Environment on the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion
by: Yu-Wang Li, et al.
Published: (2016-11-01)

Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model
by: Jamal B. Williams, et al.
Published: (2023-01-01)

IL-17A exacerbates psoriasis in a STAT3 overexpressing mouse model
by: Xinran Xie, et al.
Published: (2023-07-01)

NMDAR in bladder smooth muscle is not a pharmacotherapy target for overactive bladder in mice
by: Xiang Xie, et al.
Published: (2021-07-01)

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy
by: Shuang Chen, et al.
Published: (2022-01-01)

Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice
by: Li-Li Qiu, et al.
Published: (2020-01-01)

Pseudolycorine chloride ameliorates Th17 cell-mediated central nervous system autoimmunity by restraining myeloid-derived suppressor cell expansion
by: Gan Zhang, et al.
Published: (2022-12-01)

NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis
by: Wei-Min Han, et al.
Published: (2024-01-01)

Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat Model via Regulating NMDAR/BDNF Signaling Pathway
by: Aimei Zhao, et al.
Published: (2021-05-01)

ALLOSTERIC MODULATION OF NMDAR REVERSES ANTI-NMDAR ENCEPHALITIS IN A MOUSE MODEL OF THIS DISEASE
by: Estibaliz Maudes, et al.
Published: (2023-10-01)

NMDAR-dependent somatic potentiation of synaptic inputs is correlated with β amyloid-mediated neuronal hyperactivity
by: Yifei Bao, et al.
Published: (2021-09-01)

Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats
by: Xianchu Liu, et al.
Published: (2016-04-01)

Case Report: Anti-NMDAR Encephalitis With Anti-MOG CNS Demyelination After Recurrent CNS Demyelination
by: Bing-Yan Ren, et al.
Published: (2021-02-01)

Aloperine Ameliorates IMQ-Induced Psoriasis by Attenuating Th17 Differentiation and Facilitating Their Conversion to Treg
by: Hai-Feng Zhou, et al.
Published: (2022-06-01)

Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells
by: Li-Fei Yuan, et al.
Published: (2015-08-01)

Effects and Mechanism of Arsenic Trioxide on Reversing the Asthma Pathologies Including Th17-IL-17 Axis in a Mouse Model
by: Li Zhang, et al.
Published: (2012-06-01)

Seizures and risk of epilepsy in anti‐NMDAR, anti‐LGI1, and anti‐GABABR encephalitis
by: Chun‐Hong Shen, et al.
Published: (2020-08-01)

p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease
by: Jia-Bing Li, et al.
Published: (2023-01-01)