Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular carcinoma

Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular carcinoma

AbstractNur77 modulators have emerged as a promising therapeutic approach for hepatocellular carcinoma. In this study, a structure-based rational drug design approach was used to design and synthesise a series of 4-((8-hydroxy-2-methylquinolin-4-yl)amino)benzoylhydrazone derivatives based on the bin...

Full description

Bibliographic Details
Main Authors: Fengming He, Jun Chen, Taige Zhao, Qiaoqiong Wu, Na Yin, Xiumei Wang, Yijing Zhong, Xiaodan Guo, YingKun Qiu, Baicun Li, Meijuan Fang, Zhen Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Nur77
Benzoylhydrazone derivatives
hepatocellular carcinoma
molecular dynamics simulation
antitumor activity
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2227777

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2227777

Similar Items