Lamin A/C-Dependent Translocation of Megakaryoblastic Leukemia-1 and β-Catenin in Cyclic Strain-Induced Osteogenesis

Lamin A/C-Dependent Translocation of Megakaryoblastic Leukemia-1 and β-Catenin in Cyclic Strain-Induced Osteogenesis

Lamins are intermediate filaments that play a crucial role in sensing mechanical strain in the nucleus of cells. β-catenin and megakaryoblastic leukemia-1 (MKL1) are critical signaling molecules that need to be translocated to the nucleus for their transcription in response to mechanical strain that...

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Bibliographic Details
Main Authors: Asmat Ullah Khan, Rongmei Qu, Yuchao Yang, Tingyu Fan, Yan Peng, Bing Sun, Xianshuai Qiu, Shutong Wu, Zetong Wang, Zhitao Zhou, Muhammad Akram Khan, Jingxing Dai, Jun Ouyang
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
β-catenin
megakaryoblastic leukemia-1 (MKL1)
lamin A/C (LMNA)
mechanical strain
osteogenesis
Online Access:https://www.mdpi.com/2073-4409/10/12/3518

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https://www.mdpi.com/2073-4409/10/12/3518

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