Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4

Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4

IgA is the predominant antibody isotype at intestinal mucosae, where it plays a critical role in homeostasis and provides a first line of immune protection. Dysregulation of IgA production, however, can contribute to immunopathology, particularly in kidneys in which IgA deposition can cause nephropa...

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Bibliographic Details
Main Authors: Paolo Casali, Shili Li, Grecia Morales, Cassidy C. Daw, Daniel P. Chupp, Amanda D. Fisher, Hong Zan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
AID
B cell
class switch DNA recombination (CSR)
epigenetics
IgA
miR-146a
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.761450/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.761450/full

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