AMPK activation reverts mouse epiblast stem cells to naive state

Summary: Despite increasing knowledge on primed and naive pluripotency, the cell signaling that regulates the pluripotency type in stem cells remains not fully understood. Here we show that AMP kinase (AMPK) activators can induce the reversion of primed mouse epiblast stem cells (mEpiSCs) to the nai...

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Bibliographic Details
Main Authors: Yajing Liu, Junko Yamane, Akito Tanaka, Wataru Fujibuchi, Jun K. Yamashita
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221007513